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More important, our recent in vitro study (Lin et al., 2017) demonstrated that the extracts of menthol cigarette smoke (M-CS) can induce greater reactive oxygen species (ROS)-sensitive, TRPM8-mediated, mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in human lung epithelial cells than the extracts of non-menthol cigarette smoke (Non-M-CS) can