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There are several carcinogenic pyrolysis products, such as polynuclear aromatic hydrocarbons, which are converted by human enzymes into epoxides, which attach permanently to DNA

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A Juul spokesman said the San Francisco company is reviewing the FDA comments and will fully cooperate. In a sternly worded warning letter, the FDA flagged various claims made by Juul representatives, including that its products are much safer than cigarettes. No vaping product has been federally reviewed to be less harmful than traditional tobacco products

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