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However, in an environment of excessive stimulation, persistent Tigar expression suppresses phosphofructokinase-1 activity and glucose 6-phosphate dehydrogenase (G6PD) activity, resulting in the shutdown of the glycolysis pathway without activating the pentose phosphate pathway, ultimately leading to testicular germ cell apoptosis and infertility (62, 63)

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95% CI: 1.51-2.02) compared to children whose mothers were light smokers (OR: 1.54