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These will not only ruin your joint by possibly puncturing the paper or interrupting an otherwise even burn, TaLor says, but might also damage your grinder in the long run

Nicotine Tob Res 22:14048

The relatively high levels of NNN and NNK are consistent with the high concentrations found in Burley tobacco, which is used in these products (Ding et al., 2008)

Other causes include lack of exercise, obesity (especially in younger people), increased red meat consumption, tobacco smoking, excessive alcohol and caffeine intake, steroids and non-steroidal anti-inflammatory drugs