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Table 2 Logistic regression results: Factors associated with ever e-cigarette use among surveyed people aged 1530 years, NovemberDecember 2021 (Australia, China, India, and UK samples combined) (N=2785*) DISCUSSION E-cigarette advertising is an important modifiable factor that should be addressed to minimize vaping-related harms 8

5,40,86 Consequently, future studies should combine exposure history with single-cell transcriptomics, spatial transcriptomics, and immune phenotyping of synovial fluid and blood, so that hypotheses about macrophages, inflammasomes, and Th17/Treg imbalance can be tested directly in patient tissues rather than inferred from other organs