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Participants were evaluated at three time points: baseline (visit one), approximately 12 months later (visit two), and approximately 24 months later (visit three)

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As shown in Figure 1, a protein precipitation procedure was first carried out to remove the abundant protein components in the serum

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Heres what you can do: Use cold compresses on the area Eat mostly cold, soft foods, and avoid salty, spicy or acidic foods Suck on ice or popsicles Apply over-the-counter antiviral cold sore cream (dab it on, dont rub it in) Protect the cold sore area with a layer of petroleum jelly, or use anesthetic ointments like lidocaine or benzocaine Wear a lip balm with sunscreen to avoid sunburn Take over-the-counter pain relievers like ibuprofen or acetaminophen To avoid infection or further irritation, wait until your cold sore has scabbed over before putting makeup on it Anytime you touch a cold sore, wash your hands thoroughly before and after