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As such, even small changes in E2 levels related to the exposure to PM10 reported in our study may affect fertility

This approach allows formal testing of: (i) within-sex contrasts: whether mediation via maternal substance use is significantly larger than via paternal substance use within daughters and within sons, and (ii) between-sex contrasts: whether the strength of the mediation pathway from the same parent (e.g., maternal genetic nurture) differs significantly between daughters and sons

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and the method used to cure and process tobacco leaves once they have been harvested

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