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Confounding variables were selected based on biological plausibility and previous literature demonstrating associations with both e-cigarette use and respiratory outcomes, including age, gender, body mass index, sleep quality, and environmental exposures

which had arisen in 1967, when the Federal Communications Commission decided that its so-called Fairness Doctrine was applicable to cigarette commercials

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Supports Gradual Reduction: For those who want to gradually cut back on the habit, using a filter holder helps reduce the concentration of Nicotine slightly, creating a gentler feeling during the transition process