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Eight cigarette smokers (five of them were considered as quitters and three of them were considered as relapsers after a 12-week smoking cessation treatment) and four non-smokers were excluded owing to inordinate head motions during MR scanning, resulting in 114 subjects (73 cigarette smokers and 41 healthy non-smokers)

This is due to repeated and rapid contractions increasing metabolic demand in the muscles, swiftly depleting energy stores, and accumulating lactate, a metabolic byproduct contributing to the sensation of fatigue 17

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