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Alcohol as a culturally embedded good In many European countries, alcohol is part of the culture: Wine in Southern Europe Beer in Central Europe Social rituals and traditions This cultural embedding leads to high social acceptance despite health risks

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Hence, one might postulate that given the potentially large effect size of the aforementioned factors associated with both smoking status and IBD, that the magnitude of any direct mechanistic or toxic effect of smoking constituents on the intestinal milieu or treatment(s) might in fact be dwarfed by these cofactors, as represented in Fig

The last years of splendor The last third of the 20th century was the later period of splendor for tobacco companies