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This complex is crucial for the proteasome-dependent degradation of various growth inhibitors, including CDK inhibitors (e.g., p27, p21, p57) and tumor suppressor proteins (e.g., p130 and Tob1) (90), by facilitating their ubiquitination

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We also present the scope of genetic modifications carried out, on the one hand, to increase the usefulness of tobacco for phytoextraction of Zn/Cd from contaminated soil, and on the other, to lower the Cd content of leaves (which is important for the tobacco industry)

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