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The FDA's clearance of the products is a "major milestone in our efforts to drive meaningful change in the tobacco industry," Michael Zercher, president and COO of 22nd Century, said in a statement

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Palamidas A, Tsikrika S, Katsaounou P, Vakali S, Gennimata S-A, Kaltsakas G, Gratziou C, Koulouris N (2017) Acute effects of short term use of e-cigarettes on airways physiology and respiratory symptoms in smokers with and without airways obstructive diseases and in healthy non smokers