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Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]
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Smell and taste disturbances may occur in Lyme disease, but they should always be evaluated in the broader clinical context because many neurological, infectious, autoimmune, and ear, nose, and throat disorders can produce similar symptoms