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What often gets missed is how quickly smoking starts affecting the blood vessels

Do a few deep knee bends

Endothelial dysfunction is indicated by decreased production of vasodilatory and homeostatic molecules such as nitric oxide (NO) and prostacyclin (prostaglandin I 2 , PGI 2 ) or increased production of vasoconstrictive molecules such as endothelin-1 (ET-1) and thromboxane A 2 (TXA 2 )

Data availability The processed functionalconnectivity matrices, demographic metadata, and full analysis code for all cohorts except the musicexpertise cohort are openly available at both GitHub ( and the mirrored Zenodo archive These files are sufficient to reproduce every analysis and figure in the paper

Nicotine-free tobacco substitutes: if you like joints, mix weed with herbal tobacco substitute to avoid nicotine effects