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Following the discovery that nicotine alters the expression of the PRM1 and PRM2 genes, further studies were conducted to investigate whether various nicotine products, such as smoking and hookah, had a different impact on the expression of these protamines [86, 96, 97, 104, 105, 106]
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Tobacco-specific nitrosamines (NNAL, NNN, NAT, and NAB) exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (20132014)
Other negative health effects of dipping tobacco are oral disease, mouth lesions, receding gums, deteriorated teeth and jaw bones, increased blood pressure/heart disease, pregnancy risks, bad breath, tooth decay, and pregnancy risks
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