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The fact that i) these 8 patients were diagnosed years ago [12], ii) none of them originally experienced major vascular events (1 individual with the COL1A1 variant showed aortic ectasia, uncomplicated tortuous vertebral arteries, and left ventricular thickening), and iii) all underwent periodical vascular surveillance that resulted negative at the time of writing, suggests that the supposed genotype-phenotype correlations of these variants should not be considered valid in all cases

The campaign to pass Proposition 31 had raised around $60 million, according to campaign finance records, thanks in large part to former New York City Mayor Michael Bloomberg, who has for years fought against teen smoking and funneled millions into passing the ballot measure