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Like tobacco cigarette smoke, flavored electronic cigarette vapor has also been shown to induce pro-inflammatory markers in the brain, potentially due to nicotine, other constituents present in the vapor, or the interaction of nicotine and the constituents (158, 159)

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The incidence of coronary heart disease increases 9 to 12 times in individuals who possess all three factors: hypertension, hypercholesterolemia, and smoking