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States like New York, Massachusetts and Illinois, which all have smoke-free bans in workplaces, restaurants, bars and gambling facilities, further illustrate the impact of comprehensive smoke-free laws

One of the biggest threats to smokers is lung cancer

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Pirie K, Peto R, Reeves GK, Green J, Beral V, Million Women Study Collaborators

This natural heterogeneity complicates efforts to isolate the specific effects of smoking, as it becomes difficult to discern whether observed changes in microbial composition are due to smoking itself or interactions between smoking and other factors