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We used HLM 8.2 to specify a two-level mixed (fixed and random) effects model with this technique 29

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doi: 10.1002/art.41429 68 GuQLiDWeiBGuoYYanJMaoFet al

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That said, its important to understand that these drugs do have specific potential side effects and contraindications, with PDE5 inhibitors like sildenafil and tadalafil sometimes causing back and muscle pain, headaches, GI disturbances, and vision changes.27 Compared to research into individual drugs, theres also less robust safety data looking at how combining ED medications can affect safety