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The main issue isn't just nicotine

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Unlike the nuclear genome, mitochondrial genomes lack histones, therefore, rather than histone-related modifications, research on mitochondrial gene expression regulation focused on mtDNA methylation and has demonstrated its differences in aging [35, 36] and various diseases including metabolic disorders [37, 38], neurodegeneration [39], and cardiovascular diseases [36, 40]

Community-driven resources The tobacco industry has, and continues to, disproportionately target the LGBTQ+ and Black communities with advertising, coupons, and flavored products, leading to increased tobacco use prevalence including hookah smoking