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23,25 People who smoke heavily (20 per day) who had HPV had over twice the risk of cancer recurrence and of mortality from oropharyngeal cancer compared with those who had HPV but did not smoke

The projected 2026 value of USD 58.5 billion shows early acceleration, driven by premium devices, refill sales, and direct-to-consumer reorder models

o, this also contributes to the size difference

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