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While there are only a few medical explanations behind this, doctors have proposed numerous reasons as to why people who smoke cigarettes can increase the rate at which acid reflux events occurred

Chen G, et al

This indicates that both sample size and the context in which the intervention was delivered can influence the effect size 28

Future research to identify other susceptibility factors, such as genes that modify carcinogen metabolism or DNA repair, will need to be substantially larger and to quantify lifetime tobacco exposure with more precision than have past studies in order to distinguish gradations in risk due to exposure from those caused by genetic susceptibility

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