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But the solvents, flavorings and additives in the liquid base, after vaporization, expose users to multiple insults to the respiratory tract and blood vessels. Impact observed in volunteers who used an e-cigarette just once Wehrli noted that they observed these striking changes after the participants (all of whom never smoked previously) used an e-cigarette a single time

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and the percentage of 11-17 year olds who have used an e-cigarette in the past month has doubled in Italy since 2014 and increased significantly in Latvia and Romania

doi: 10.1136/tobaccocontrol-2021-056544

The agent then puts out another random two of the three ingredients, and the cycle repeats