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According to Bradford Hills criteria of temporality and biological gradient, the observed doseresponse and timing patterns strengthen the plausibility of a causal relationship [44]

But I think that someone in the U.S

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Given that, it should be used as a descriptor so other healthcare professionals and providers know that their history of nicotine dependence plays a role in what the patient is dealing with

Although several carcinogens were already known at the time (for example, benzo[a]pyrene was isolated from coal tar and demonstrated to be a potent carcinogen in 1933), none were known to be contained in adequate quantities in tobacco smoke