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52.2%) were ex-smokers
Clinical outcome was defined as death in 7 studies [12, 16, 26, 33, 34, 45, 54], intensive care unit (ICU) admission or requirement of mechanical ventilation in 6 studies [8, 10, 15, 17, 21, 23], prolonged viral shredding in 2 studies [43, 44], severe or critical (respiratory distress with respiratory rate 30/min, or oxygen saturation 93% at rest, or oxygenation index 300 mmHg, based on the diagnostic and treatment guideline for SARS-CoV-2 issued by Chinese National Health Committee [55] or the American Thoracic Society guidelines [56] for community acquired pneumonia) in 18 studies, the primary composite end point (ICU admission, the use of mechanical ventilation, or death) in 2 studies [18, 47], abnormal chest imaging in 1 study [52], acute cardiac injury in 1 study [19], progression of disease to more severe status (including increasing oxygen supplement, pneumonia exacerbation, transferred to ICU, and sepsis) in 10 studies [13, 20, 24, 25, 30, 32, 34, 37, 38, 48]
Boulder, Colorado, is backdropped with hogbacks (the Flatirons), which are more of the same Pennsylvanian strata leaning against the Front Range
The tins above tend to be fairly common and usually can be acquired on eBay, Etsy, or Ruby Lane from someone at any given time
