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Indeed, the use of extreme conditions increases the likelihood of eliciting a response, potentially allowing for small effects to be observed that would otherwise be missed or represented as no result and also allowing comparisons to combustible cigarettes via EC 50 values

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He was assisted in this operation by a feeling that he was performing a service to the masses in a time of depression and (perhaps more important) by Fanchon & Marco, a firm of theatrical booking agents he hired to run the stage-show end of his enterprise