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[92] Corticotropin-releasing factor, Neuropeptide Y, orexins, and norepinephrine are involved in nicotine addiction

Smoking acutely activates the HPA axis resulting in increased cortisol levels [6,18], and nicotine is the principal component of tobacco responsible for the stimulation of the HPA axis [19]

[PubMed: 9676508] Wang MQ, Fitzhugh EC, Eddy JM, Westerfield RC

I've long recognized the potential catastrophe of banning full nicotine cigarettes